- 著者
- YUMIKO NITTA SATORU ENDO NARIAKI FUJIMOTO KENJI KAMIYA MASAHARU HOSHI
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.42, no.2, pp.143-155, 2001 (Released:2001-10-27)
- 参考文献数
- 28
- 被引用文献数
- 5 4
Female rats of the Fischer 344 strain at ages of 1, 4 and 9 weeks were exposed to 131I intraperitoneally with activities of 0.38, 1.03 and 3.42 kBq per gram of body weight under the condition of iodine deficiency. The absorbed doses in the thyroid increased linearly depending on the injected activities. Irradiation at 1 week old caused heavier exposure than those at 4 and 9 weeks old by 7.5 and 7.7 times, respectively; however, damage of the thyroid tissue was more obvious in the 4-week-old groups than in the 1-week-old groups. The absorbed doses in the total body were proportional to the square root of the injected activities. The one-week-old groups were exposed more heavily than the 4- and 9-week-old groups by 3.6 and 4.7 times, respectively, shown by the slow excretion of 131I with the values of effective half-life of 131I activity (Teff). An IDD-treatment was not so effective to enhance the 131I absorption in the total body, as in the thyroid. No matter how the iodine concentration in the blood changed, the 1-week-old groups could not react to normalize the level. We drew standard curves, which enabled us to estimate the absorbed doses in the thyroid and the total body in the case of the injected activities of 131I for the newborn, pubertal and adult rats.
- 著者
- Nobuo TAKEICHI Masaharu HOSHI Shozo IIDA Kimio TANAKA Yuka HARADA Zhaxybay ZHUMADILOV Nailya CHAIZHUNUSOVA Kazbek N. APSALIKOV Yoshihiro NOSO Toshiya INABA Kenichi TANAKA Satoru ENDO
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.47, no.SupplementA, pp.A171-A177, 2006 (Released:2006-03-28)
- 参考文献数
- 25
- 被引用文献数
- 9
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.
- 著者
- JUN TAKADA MASAHARU HOSHI SHOZOH SAWADA MASANOBU SAKANOUE
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.24, no.3, pp.229-236, 1983-09-15 (Released:2006-06-16)
- 参考文献数
- 14
- 被引用文献数
- 9 11 9
Uranium isotopes were studied to clarify the fallout from the Hiroshima atomic bomb. The 234U/238U activity ratios of uranium leached from the soil in the Hiroshima fallout area were significantly higher than those of other areas according to alpha ray spectrometry. The correlation of specific activity of the fission product 137Cs and the 234U/238U activity ratios was studied. Two different correlations were established inside and outside the fallout area. The results of this study suggest that manifestations of fallout from the Hiroshima atomic bomb are still detectable in the “black rain” area.
- 著者
- Deborshi BHATTACHARJEE Alexander I. IVANNIKOV Kassym ZHUMADILOV Valeriy F. STEPANENKO Kenichi TANAKA Satoru ENDO Megu OHTAKI Shin TOYODA Joyeeta BHATTACHARYYA Masaharu HOSHI
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.50, no.6, pp.559-565, 2009 (Released:2009-12-04)
- 参考文献数
- 24
Electron spin resonance (ESR) dosimetry of teeth is used extensively for dose estimation following exposure to radiation. The population inhabiting the northeast region of India is prone to different cancers of the head and neck, and their prevalence is several times the national average. The objective of this study was to determine the role of radiation in the causation of this high cancer incidence by performing ESR spectroscopic measurements of tooth samples collected from the general population living in and around the city of Silchar. Nineteen tooth samples were used, and the age of the patients was 13-60 years. The excess dose, determined by subtraction of the natural background dose from the dose absorbed by the enamel, was found to the extent of 123 ± 43 mGy. However, the individual excess dose was found to be higher in subjects who consumed lime (5/6) than in non-lime-consuming subjects (2/13). It is not entirely clear if radiation is the cause of this excess cancer in this region of India. Therefore there is a need for wider studies including consideration of tobacco consumption as well as a larger number of samples for tooth enamel dosimetry.
- 著者
- Dinara ZHARLYGANOVA Hironori HARADA Yuka HARADA Sergey SHINKAREV Zhaxybay ZHUMADILOV Aigul ZHUNUSOVA Naylya J. TCHAIZHUNUSOVA Kazbek N. APSALIKOV Vadim KEMAIKIN Kassym ZHUMADILOV Noriyuki KAWANO Akiro KIMURA Masaharu HOSHI
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.49, no.5, pp.549-555, 2008 (Released:2008-09-19)
- 参考文献数
- 33
- 被引用文献数
- 17
It is known that bone marrow is a sensitive organ to ionizing radiation, and many patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) have been diagnosed in radiation-treated cases and atomic bomb survivors in Hiroshima and Nagasaki. The AML1/RUNX1 gene has been known to be frequently mutated in MDS/AML patients among atomic bomb survivors and radiation therapy-related MDS/AML patients. In this study, we investigated the AML1 mutations in radiation-exposed patients with MDS/AML among the residents near the Semipalatinsk Nuclear Test Site (SNTS), where the risk of solid cancers and leukemias was increased due to the radiation effects. AML1 mutations were identified in 7 (39%) of 18 radiation-exposed MDS/AML patients. In contrast, no AML1 mutation was found in 13 unexposed MDS/AML cases. The frequency of AML1 mutations in radiation-exposed patients with MDS/AML was significantly higher compared with unexposed patients (p < 0.05).We also found a significant correlation between individual estimated doses and AML1 mutations (p < 0.05). Considering these results, AML1 point mutations might be a useful biomarker that differentiates radio-induced MDS/AML from spontaneous MDS/AML.