著者
Kazuki Nakanishi Macoto Kikuchi
出版者
THE PHYSICAL SOCIETY OF JAPAN
雑誌
Journal of the Physical Society of Japan (ISSN:00319015)
巻号頁・発行日
vol.75, no.6, pp.064803, 2006-06-15 (Released:2009-08-27)
参考文献数
17
被引用文献数
4

We investigate aggregation mechanism of two proteins in a thermodynamically unambiguous manner by considering the finite size effect of free energy landscape of HP lattice protein model. Multi-self-overlap-ensemble Monte Carlo method is used for numerical calculations. We find that a dimer can be formed spontaneously as a thermodynamically stable state when the system is small enough. It implies the possibility that the aggregation of proteins in a cell is triggered when they are confined in a small region by, for example, being surrounded by other macromolecules. We also find that the dimer exhibits a transition between unstable state and metastable state in the infinite system.