- 著者
- Manami MONOBE Akiko UZAWA Makiko HINO Koichi ANDO Shuji KOJIMA
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.46, no.1, pp.117-121, 2005 (Released:2005-04-01)
- 参考文献数
- 23
- 被引用文献数
- 21
Human whole-blood was exposed to 137Cs γ-rays or 50 keV/μm carbon ions in the presence or absence of glycine betaine, a beer component in vitro. The dicentrics of chromosome aberrations in human lymphocytes were significantly (p < 0.05) reduced by glycine betaine after irradiation with 4 Gy of either γ-rays or carbon ions. The maximum protection by glycine betaine for γ-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14 weeks, received an i.p. injection of glycine betaine 15 min before whole-body irradiation with γ-rays or 50 keV/μm carbon ions. Glycine betaine significantly (p < 0.05) increased the percent survival of irradiated mice with either γ-rays or carbon ions. In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.