- 著者
- Marwa AKAO Joohyeon WOO Shingo IWAMI Shoya IWANAMI
- 出版者
- Catalyst Unit
- 雑誌
- Translational and Regulatory Sciences (ISSN:24344974)
- 巻号頁・発行日
- vol.3, no.3, pp.85-88, 2021 (Released:2021-12-24)
- 参考文献数
- 13
- 被引用文献数
- 1
To evaluate the effects of antiviral drugs against coronavirus disease (COVID-19), we calculated the sample size needed to detect significant differences in daily viral load in randomized controlled trials. While calculating sample sizes, simulated viral loads that mimicked longitudinal clinical data were used. The sample size computed from the viral load was the smallest 2 to 4 days after trial participation, while the smallest sample size computed from the positive rate was 4 to 7 days after clinical trial participation.