- 著者
- Masaaki ISHIKAWA Ken-ichi SASAKI Yoshio TAKAYANAGI
- 出版者
- (社)日本薬理学会
- 雑誌
- The Japanese Journal of Pharmacology (ISSN:00215198)
- 巻号頁・発行日
- vol.51, no.1, pp.146-149, 1989 (Released:2006-08-25)
- 参考文献数
- 15
- 被引用文献数
- 8 10 12
The effect of buthionine sulfoximine (BSO), a glutathione biosynthesis inhibitor, on the acute lethal toxicity and urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/ kg, i.p.) 5 hr prior to CPA resulted in enhanced lethality and urotoxicity of CPA. In contrast, administration of cysteamine decreased the lethality and urotoxicity of CPA.