著者

Masaaki Tagawa Michiko Kano Nobuyuki Okamura Masatoshi Itoh Eiko Sakurai Takehiko Watanabe Kazuhiko Yanai

出版者

The Japanese Pharmacological Society

雑誌

The Japanese Journal of Pharmacology (ISSN:00215198)

巻号頁・発行日

vol.83, no.3, pp.253-260, 2000 (Released:2001-01-31)

参考文献数

46

被引用文献数

16 14

---

Ethanol is a social drug and has been generally known to be a CNS depressant.A large fluctuation of blood alcohol concentration(BAC)is well−known to occur due to main factors such as the genetic polymorphism of the main alcohol metabolizing enzymes and the effect of blood.Few studies have substantially discussed the relationship between impaired CNS activities and BAC.In this study, focusing on the correlation of BAC, we investigated the acute effects of alcohol intake on cognitive performance in humans by objective evaluation methods consisting of the attention−demanding cognitive tasks.Tasks were administered to ten healthy male volunteers before and after ingesting established amounts of alcohol.With increased BAC, we observed prolongation of reaction time performances and lowering of a coordination performance.From the results, we concluded that cognitive performance deteriorates with an increase of BAC.Additionally, the BAC threshold that causes significant impairment of cognitive performance was estimated to be approximately 50 mg/dl(ca.10 mM).