著者

Tamio OHNO Yuki MIYASAKA Masako KUGA Kaori USHIDA Miyoko MATSUSHIMA Tsutomu KAWABE Yoshiaki KIKKAWA Masashi MIZUNO Masahide TAKAHASHI

出版者

Japanese Association for Laboratory Animal Science

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

pp.18-0185, (Released:2019-03-15)

被引用文献数

3

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Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral malaria and nephrotic syndrome, in addition to a rapid increase in parasitemia. Here, we focus on the analysis of host genetic factors that affect malarial pathogenesis and describe the characteristic features, utility, and future prospects for exploitation of the NC/Jic strain as a novel mouse model for malaria research.

著者

Naoki Tarutani Miki Asanome Kenji Okada Masahide Takahashi Takuo Minato Masahiro Sadakane Kiyofumi Katagiri Kei Inumaru

出版者

The Ceramic Society of Japan

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.131, no.10, pp.830-836, 2023-10-01 (Released:2023-10-01)

参考文献数

44

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Additive manufacturing by vat-photopolymerization is important technique to prepare designed objects because of its features of availability, low cost, low energy consumption, and high-speed printing. One of the major challenges of this technique is how to expand the chemical composition towards metals and ceramics in addition to organic compounds. In this paper, we report synthesis of highly concentrated nanocolloids of nickel hydroxide acrylate and use them for vat-photopolymerization. Epoxide-mediated basification induced formation of dispersed nickel hydroxide acrylate monolayer/bilayer nanoparticles (diameter of 2.31 nm). The concentration of nanocolloid was prepared as 2.5 mol L−1 (Ni basis), which corresponds to 43 wt % and 30 vol %. The concentrated nanocolloids enabled to produce objects through vat-photopolymerization by using commercially available 3D printers. Addition of small quantity of organic cross-linker efficiently interconnect nanoparticles to form bulky objects. Owing to the organic moiety of nickel hydroxide salt nanoparticles, metal/carbon composites formed by heat-treatment without any reduction gas supply. Further heat-treatment led metal oxide bulky object with macroporous structure.