著者

Hirokatsu Takahashi Shoichi Ito Shigeki Hirano Masahiro Mori Yasuo Suganuma Takamichi Hattori

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.45, no.10, pp.705-706, 2006 (Released:2006-06-15)

参考文献数

2

被引用文献数

5 6

著者

Akiyuki Uzawa Masahiro Mori Yuta Iwai Hiroki Masuda Satoshi Kuwabara

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.18, pp.2785-2787, 2022-09-15 (Released:2022-09-15)

参考文献数

10

被引用文献数

4

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Satralizumab, a monoclonal antibody against interleukin-6 receptors, has been approved for the treatment of neuromyelitis optica spectrum disorder (NMOSD). Several reports have described the effectiveness of satralizumab against neuropathic pain in patients with NMOSD, but its effects on painful tonic seizures have not yet been reported. We herein report a Japanese woman with anti-aquaporin-4 antibody-positive NMOSD whose painful tonic seizures completely resolved after six months of satralizumab treatment. In conclusion, interleukin-6 blocking may be effective against painful tonic seizures. This effect may be due to suppression of microglial activation and the resultant neuronal hyperexcitability.