- 著者
- Kazuhiro Morisaki Yuta Kondo Masanao Sawa Hiroyuki Morimoto Takashi Ohshima
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.65, no.11, pp.1089-1092, 2017-11-01 (Released:2017-11-01)
- 参考文献数
- 20
- 被引用文献数
- 1
This note describes the construction of tetrasubstituted carbon stereocenters via palladium-catalyzed allylation of sp3 C–H bonds of 2,2,2-trifluoroethylamine derivatives. The presence of 2-pyridyl group of the imines derived from 1-substituted-2,2,2-trifluoroethylamine was key to promoting the reaction efficiently, allowing an access to a variety of 1-allylated 2,2,2-trifluoroethylamine derivatives with tetrasubstituted carbon stereocenters.