著者

Yasutaka Mochizuka Masato Kono Mineo Katsumata Ryutaro Hirama Masayuki Watanuki Yuiko Oshima Kenichiro Takeda Akari Tsutsumi Hideki Miwa Yoshihiro Miki Dai Hashimoto Noriyuki Enomoto Yutaro Nakamura Takafumi Suda Hidenori Nakamura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.7533-21, (Released:2021-07-30)

参考文献数

18

被引用文献数

3

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A 67-year-old man was admitted to our hospital with cough and fatigue. He had had long-term exposure to silica due to cement processing. Chest computed tomography showed bilateral centrilobular nodules, and hilar and mediastinal lymphadenopathy with calcification, suggesting chronic silicosis. Within a few months, these nodules enlarged, and bilateral patchy consolidations appeared. A lung biopsy revealed sarcoid-like granulomas with birefringent particles under polarized light without malignancy or infection. He was diagnosed with silicosis-associated sarcoid-like granulomatous lung disease, rather than sarcoidosis, according to the clinicopathological findings. His pulmonary manifestations improved after the discontinuation of silica exposure and combination therapy of corticosteroid and azathioprine.

著者

Yoshinori Hashimoto Masato Kono Shingo Harada Tetsuhiro Nemoto

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.66, no.11, pp.1041-1047, 2018-11-01 (Released:2018-11-01)

参考文献数

43

被引用文献数

8

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We developed the first carbenoid insertion reaction into the urea C−N bond. The urea insertion reaction proceeded smoothly using Rh2(NHPiv)4, a rhodium catalyst previously designed by our group, to construct a diazabicyclic system. Highly functionalized bridged molecules with three adjacent stereocenters were diastereoselectively synthesized via the urea insertion reaction followed by hydride reduction or nucleophilic addition sequences in one-pot.