著者

Masaya MIYAZONO Katsunori TORII Mayu YAMAMOTO Junko TANAKA Masahiro TANAKA

出版者

Osaka Odontological Society

雑誌

Journal of Osaka Dental University (ISSN:04752058)

巻号頁・発行日

vol.53, no.2, pp.179-186, 2019-10-25 (Released:2020-01-25)

参考文献数

22

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We attempted to clarify how the impressions imparted on observers are affected by smiles with exposed teeth. Sixty young adults participated in the study, 23 men and 37 women, who had a mean age of 23±2 years. Impressions of composite (average) male and female faces were rated to eliminate individual bias. Ten facial photos were processed for each of 10 adult males with a mean age of 25±2 years and 10 adult females with a mean age of 26±1 years. Three stimulus images were used for each gender: a neutral face (teeth hidden), a smiling face (teeth hidden), and a grinning face (teeth exposed). The average male faces were rated by 30 subjects and the average female faces by the other 30. The semantic differential method was used to rate the impressions. Group ratings were then subjected to factor analysis. The two common factors having the greatest explanatory power were: “Sociable" and “Active" for the male stimulus images and “Friendly" and “Elegant" for the females. Significant differences between stimuli were observed for scores on both the first and second factors. In all cases, the grin was rated highest, followed by the smile and neutral face. We found that when smiling with the teeth exposed, male faces give a strong impression of sociability and activity, while females give a strong impression of friendliness and elegance. (J Osaka Dent Univ 2019; 53: 179‐186)

著者

Kanae Sasaki Ryota Komori Mai Taniguchi Akie Shimaoka Sachiko Midori Mayu Yamamoto Chiho Okuda Ryuya Tanaka Miyu Sakamoto Sadao Wakabayashi Hiderou Yoshida

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.18031, (Released:2018-11-28)

被引用文献数

14

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The Golgi stress response is a homeostatic mechanism that augments the functional capacity of the Golgi apparatus when Golgi function becomes insufficient (Golgi stress). Three response pathways of the Golgi stress response have been identified in mammalian cells, the TFE3, HSP47 and CREB3 pathways, which augment the capacity of specific Golgi functions such as N-glycosylation, anti-apoptotic activity and pro-apoptotic activity, respectively. On the contrary, glycosylation of proteoglycans (PGs) is another important function of the Golgi, although the response pathway upregulating expression of glycosylation enzymes for PGs in response to Golgi stress remains unknown. Here, we found that expression of glycosylation enzymes for PGs was induced upon insufficiency of PG glycosylation capacity in the Golgi (PG-Golgi stress), and that transcriptional induction of genes encoding glycosylation enzymes for PGs was independent of the known Golgi stress response pathways and ER stress response. Promoter analyses of genes encoding these glycosylation enzymes revealed the novel enhancer elements PGSE-A and PGSE-B (the consensus sequences are CCGGGGCGGGGCG and TTTTACAATTGGTC, respectively), which regulates their transcriptional induction upon PG-Golgi stress. From these observations, the response pathway we discovered is a novel Golgi stress response pathway, which we have named the PG pathway. Key words: Golgi stress, proteoglycan, ER stress, organelle zone, organelle autoregulation