- 著者
- Taiki Miyazawa Kiyotaka Nakagawa Fumiko Kimura Yuya Nakashima Isao Maruyama Ohki Higuchi Teruo Miyazawa
- 出版者
- 公益社団法人 日本油化学会
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.62, no.10, pp.773-779, 2013 (Released:2013-10-02)
- 参考文献数
- 22
- 被引用文献数
- 3 20
Chlorella contains a high amount of carotenoids, especially lutein, and has received attention as a possible dietary source for improving carotenoid levels in human blood. In the present study, we performed a 2-month single arm human study, and investigated the efficacy of Chlorella supplementation (9 g Chlorella/day; equivalent to 32 mg lutein/day) on lutein and other carotenoid concentrations in plasma as well as erythrocytes of 12 healthy subjects. Following Chlorella supplementation, lutein was the predominant carotenoid in erythrocytes, showing a 4-fold increase (from 14 to 54 pmol/mL packed cells). After the one month without Chlorella ingestion, erythrocyte lutein then decreased to a basal level (17 pmol/mL packed cells). Erythrocyte carotenoid (lutein, zeaxanthin, α-carotene, and β-carotene) levels were proportional to plasma carotenoid levels. The results suggest the transfer of Chlorella carotenoids, especially lutein, from plasma lipoprotein particles to the erythrocyte membrane. Chlorella intake would be effective for improving and maintaining lutein concentrations in human erythrocytes.
- 著者
- Taiki Miyazawa Kiyotaka Nakagawa Hideo Takekoshi Ohki Higuchi Shunji Kato Momoko Kondo Fumiko Kimura Teruo Miyazawa
- 出版者
- 公益社団法人 日本油化学会
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.62, no.11, pp.873-881, 2013 (Released:2013-11-06)
- 参考文献数
- 22
- 被引用文献数
- 3 25
Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact for a total of 2 months Chlorella supplementation (8 g Chlorella/day/person; equivalent to 22.9 mg lutein/day/person) on PLOOH and carotenoid concentrations in erythrocytes as well as plasma of 12 normal senior subjects. After 1 or 2 months of treatment, erythrocytes and plasma lutein concentrations increased in the Chlorella group but not in the placebo group. In the Chlorella-supplemented group, erythrocyte PLOOH concentrations after a total of 2 months of treatment were lower than the concentrations before supplementation. These results suggest that Chlorella ingestion improved erythrocyte antioxidant status and lowered PLOOH concentrations. These reductions might contribute to maintaining the normal function of erythrocytes and prevent the development of senile dementia.
- 著者
- Taiki MIYAZAWA Ohki HIGUCHI Masato SASAKI Minh Tu NGUYEN THI Teruo MIYAZAWA
- 出版者
- Center for Academic Publications Japan
- 雑誌
- Journal of Nutritional Science and Vitaminology (ISSN:03014800)
- 巻号頁・発行日
- vol.68, no.2, pp.137-139, 2022-04-30 (Released:2022-04-30)
- 参考文献数
- 12
Turmeric products have many useful physiological functions and are widely used as health food and food ingredient. Here, we report the use of HPLC-ESI-MS/MS to simultaneously quantify bisacurone and three curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in turmeric products (high viscosity liquid, granular powder, tablet, and solution). The results showed that the standard values and measured values of curcumin in each product were almost same. Demethoxycurcumin and bisdemethoxycurcumin were contained in each products. Meanwhile, the content of bisacurone differed greatly among the products. In particular, the highest amount of bisacurone was found in the turmeric product A (high viscosity liquid, 9.48 g/100 g product). It would become important to consider the bisacurone content in turmeric products.