著者

Hua-Yong CHEN Peng CUI Xiao-Qing CHEN JinBo TANG

出版者

社団法人 砂防学会

雑誌

International Journal of Erosion Control Engineering (ISSN:18826547)

巻号頁・発行日

vol.10, no.1, pp.9-15, 2017 (Released:2017-03-24)

参考文献数

19

被引用文献数

6

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In this article, experimental tests were conducted to study the characteristics of the surge wave and its effects on the failure process of a glacier dam. The results indicated that two obvious surges were monitored by pore pressure transducers (PPTs) when the blockage slid into water. The surge wave attenuated exponentially near the plunging location and then attenuated slowly when it propagated downstream. When the surge wave reached the glacier dam it climbed up along the dam and flew over. Sequential propagating surges exerting on the dam were one of the main factors causing the failure of the glacier dam. The failure mechanism of glacier dam triggered by the surge waves under different initial water supply conditions was primarily analyzed in this article.

著者

Liu Weiping Qing Chen Chen Xizhu YE Qingsong YU Yao HOU Shuqian

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.56, no.5, pp.659-662, 2008-05-01

被引用文献数

1 6

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New JM118 (active form of satraplatin) analogues with N-cyclohexyl-1,3-propanediamine (N-chpda) as the carrier, cis-[Pt(N-chpda)X_2] (X_2=2Cl^- (1), oxalate (2), malonate (3), 1,1-cyclobutanedicarboxylate (CBDCA) (3), and 3-hydroxy-1,1-cyclobutanedicarboxylate(HO-CBDCA) (4)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative compound cis-[Pt(N-chpda)Cl_2]. The complexes have also been evaluated for their in vitro anticancer activity. All these analytical data are in good agreement with the structures of the desired compounds. The Pt(II) is in a square planar environment and is coordinated by a chelating N-chpda ligand and 2Cl^- in cis position, and there are two crystallo-graphically independent cis-[Pt(N-chpda)Cl_2] molecules linked together by intermolecular N-H…Cl hydrogen bonds. Compounds 1 and 2 are very active against human lung cancer cell line (AGZY) and human lymphocytic leukemia cell line (Raji), and are much more active than carboplatin. Platinum(II) complexes with N-cyclohexyl-1,3-propanediamine is an alternative choice for mixed ammine/aminoplatinum anticancer drugs.