- 著者
- Motohide Furuya Tsuyoshi Miyaoka Sadayuki Hashioka Rei Wake Keiko Tsuchie Jun Horiguchi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.44, pp.34-41, 2014-12-30 (Released:2017-06-01)
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.
- 著者
- Rei Wake Tsuyoshi Miyaoka Kazunori Kawakami Motohide Furuya Masa Ieda Liaury Kristian Keiko Tsuchie Akira Nishida Takuji Inagaki Jun Horiguchi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.36, pp.4-17, 2011-03-30 (Released:2017-06-01)
- 参考文献数
- 39
Objective: We attempted to identify the locus of cerebral blood flow reduction to clarify the functional neuroanatomical basis of the first-episode schizophrenia. A secondary objective was to evaluate the diagnostic value a new analytical program, easy Z-score Imaging System (eZIS). Method: We performed single photon emission computed tomography (SPECT) with 99-Tc-ethyl cysteinate dimmer (^<99m>Tc-ECD) of the brains of patients with the first-episode schizophrenia (n=30) and normal controls (n=37) and evaluated the diagnostic value of brain perfusion SPECT using eZIS on patients with schizophrenia. Result: In comparison with normal controls, the patients with schizophrenia were found to have reduced blood flow in bilateral frontal and temporal areas. Conclusion: In our study, patients with the first-episode schizophrenia appeared to have significant bilateral fronto-temporal hypoperfusion. Demonstration of abnormality of frontal and temporal lobe blood flow may assist in the diagnosis of schizophrenia and determination of appropriate treatment for individuals with schizophrenia.