- 著者
- Yuji Yamamoto Yuko Ohara Ami Iwai Reina Hara Takanori Matsuki Kiyoharu Fukushima Yohei Oshitani Hiroyuki Kagawa Kazuyuki Tsujino Kenji Yoshimura Mari Miki Keisuke Miki Masahide Mori Hiroshi Kida
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.3991-19, (Released:2020-03-19)
- 参考文献数
- 15
- 被引用文献数
- 1 5
Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse therapy, intravenous immunoglobulin, and temporary mechanical ventilation, and eventually he made a full recovery. Vaccine-related thrombocytopenia and DAH should be considered adverse reactions, even if they develop very soon after vaccination.