著者

Kenichi Mori Keiko Wada Kie Konishi Yuko Goto Fumi Mizuta Sachi Koda Takahiro Uji Yatsuji Ito Chisato Nagata

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.29, no.2, pp.61-64, 2019-02-05 (Released:2019-02-05)

参考文献数

21

---

Background: Cedar pollinosis is one of the most prevalent forms of seasonal allergic reaction in Japan. Only one prospective study has examined the association between cedar pollinosis and mortality. Using a symptom-based questionnaire on cedar pollinosis, we investigated the association of cedar pollinosis with all-cause and cause-specific mortality.Methods: Data came from the Takayama Study, which recruited residents aged ≥35 years in 1992 from Takayama city in Gifu Prefecture, Japan. The current study used information on cedar pollinosis that was obtained from the second survey in 2002. A total of 12,471 persons who were 45–80 years old and had no history of cancer, coronary heart disease, or stroke responded to a questionnaire asking about four symptoms related to cedar pollinosis. Mortality and migration data were obtained throughout the follow-up period up to March 2013. Cox proportional hazard models were used to examine the relation between cedar pollinosis and mortality.Results: A total of 1,276 persons died during follow-up period. Among these, there were 504 neoplasm, 278 cardiovascular, and 181 respiratory deaths. After adjusting for potential confounders, cedar pollinosis was associated with significantly lower all-cause mortality (hazard ratio [HR] 0.79; 95% confidence interval [CI], 0.65–0.95) and respiratory mortality (HR 0.38; 95% CI, 0.18–0.82). There was no significant association between cedar pollinosis and mortality due to neoplasm or cardiovascular disease.Conclusions: We found an inverse association between cedar pollinosis and the risk of all-cause and respiratory mortality. Further research is needed to elucidate the association between cedar pollinosis and mortality.

著者

Yuko Goto Keiko Wada Takahiro Uji Sachi Koda Fumi Mizuta Michiyo Yamakawa Chisato Nagata

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20180243, (Released:2019-04-20)

参考文献数

29

被引用文献数

17

---

Background: The association between the number of teeth and mortality among community-dwelling people has been examined in many epidemiological studies. However, few Japanese studies have included cancer mortality as an endpoint. We prospectively investigated the association between number of remaining teeth and all-cause and cancer mortality in a Japanese community.Methods: This study included participants in the Takayama study who were aged 35–70 years old at baseline in 1992. Information on the number of remaining teeth was obtained from 11,273 participants via questionnaire at the second survey in 2002. The response rate was 66.9%. Deaths and their causes were ascertained during 11.8 years of follow-up.Results: A total of 1098 deaths (435 cancer-related and 235 cardiovascular-related) were identified during the follow-up period. After adjusting for covariates, participants with 0 to 9 teeth were at moderate but significantly increased risk of all-cause mortality (hazard ratio [HR] 1.19; 95% confidence interval [CI], 1.03–1.39) and cancer mortality (HR 1.31; 95% CI, 1.03–1.67) as compared to those with 20 or more teeth. With regard to cancer site, a significant association was observed for lung cancer (HR for 0–9 teeth vs. 20 or more teeth, 1.75; 95% CI, 1.08–2.83). This association was somewhat strengthened among never-smokers (HR 3.56; 95% CI, 1.02–12.45).Conclusions: We observed that a lower number of remaining teeth was significantly associated with increased risk from all-cause and lung cancer mortality. Further studies on the number of teeth and lung and other types of cancer are needed.