- 著者
- Sadanobu ABE
- 出版者
- Japan Society of Smooth Muscle Research
- 雑誌
- Journal of Smooth Muscle Research (ISSN:09168737)
- 巻号頁・発行日
- vol.30, no.3, pp.97-110, 1994 (Released:2010-07-21)
- 参考文献数
- 40
- 被引用文献数
- 4 4
Dysmotility of lower esophageal sphincter (LES) is common follwing gastric surgery. This may result in gastroesophageal reflux which freqently seen following gastric surgery. The aim of this study was to determine the effect of various surgical procedures on esophagogastric motility in dog and human. Esophago-gastric motillity was investigated by strain gauge transducers during fasted and fed state in conscious dogs. Motility recordings were performed in three groups of dogs, 1) control dogs, 2) with truncal vagotomized dogs (TV), 3) with selective proximal vagotomized dogs (SPV). In human, manometric recordings were performed before and after gastric surgery (SPV or distal partial gastrectomy). In control animals, lower esophagus and LES contracted simultaneously with each contractions of the stomach during interdigesive moter contractions in fasted state. In fed state, LES showed tonic contractions, while gastric body showed receptive relaxation. These motility pattern of LES was considerd to prevent gastroesophageal reflux in both fasted and fed states. These coordinated LES contractions disappeared following SPV or TV. In human, the amplitude and velocity of esophageal propagating contractions deceased after SPV or distal partial gastrectomy. In conclusion, gastric surgeries such as SPV, TV and/or distal partial gastrectomy caused LES dysmotility. These phenomena explain frequent gastroesophageal reflux following gastric surgery. Suplementation of anti-reflux procedure for gastric surgery should be required in the prevention of gastroeso-phageal reflux following gastric surgery.