- 著者
- Shinobu Hazama Satoshi Ichikawa Fumihiro Yonebayashi
- 出版者
- Japanese Association of Forensic Science and Technology
- 雑誌
- 日本法科学技術学会誌 (ISSN:18801323)
- 巻号頁・発行日
- vol.13, no.1, pp.67-72, 2008 (Released:2008-04-19)
- 参考文献数
- 13
Enantioselective analysis of methamphetamine (MA) and amphetamine (AP) is necessary in forensic drug analysis. In general, standard materials are required for performing forensic investigation and also for developing new analytical methods. However, l-MA is not commercially available in Japan and only a few reports are available on the enantioselective synthesis of l-MA. We developed a new and convenient method for the synthesis of l-MA using d-norephedrine (d-NE) as a starting material. d-NE was treated with 1,1′-carbonyldiimidazole to produce the corresponding cyclic carbonate, and the product was treated with sodium hydride and iodomethane to form mono-N-methylated amine derivative, which was treated with palladium on activated carbon in hydrogen atmosphere for catalytic reduction. After the addition of aqueous hydrogen chloride (HCl), l-MA was obtained as its HCl salt (total yield 58%).
- 著者
- Akira Katsuyama Kousuke Sato Fumika Yakushiji Takanori Matsumaru Satoshi Ichikawa
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.66, no.1, pp.84-95, 2018-01-01 (Released:2018-01-01)
- 参考文献数
- 25
- 被引用文献数
- 11
A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.