著者
Eisuke SATO Sayaka OGITA Koichi MITSUDO Seiji SUGA
出版者
The Electrochemical Society of Japan
雑誌
Electrochemistry (ISSN:13443542)
巻号頁・発行日
vol.91, no.11, pp.112005, 2023-11-28 (Released:2023-11-28)
参考文献数
26

Cathodic reduction efficiently cleaved N–O bonds. The simple cathodic reduction of Weinreb amides in a divided cell afforded the corresponding amide in good yields. Cyclic voltammetry experiments and density functional theory calculations suggested that the direct reduction of the N-methoxy amide generates the methoxy radical and amide anion. The release of methanol derived from methoxy radical would be the driving force of the N–O bond cleavage.