- 著者
- Mika Kawagoe Kohei Odajima Shinichiro Asakawa Michito Nagura Shigeyuki Arai Osamu Yamazaki Yoshifuru Tamura Ryuji Ohashi Takamasa Iwakura Hideo Yasuda Shigeru Shibata Yoshihide Fujigaki
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.1251-22, (Released:2023-03-22)
- 参考文献数
- 27
Exostosin 1 (EXT1) and exostosin 2 (EXT2)-associated membranous nephropathy (MN) may be associated with active autoimmune disease. We encountered an elderly man who presented with EXT1/EXT2-associated lupus-like MN with full house immune deposits, monoclonal gammopathy of uncertain significance and Sjögren's syndrome. The patient exhibited various other immune abnormalities. Although he did not fulfill the criteria of clinical systemic lupus erythematosus (SLE), he met a stand-alone renal criterion of SLICC 2012. Whether or not a stand-alone renal criterion with EXT1/EXT2 positivity, as in the present patient, can efficiently guide decisions regarding the diagnosis and treatment of SLE remains a clinical dilemma.