著者

Toshihiro Kawaguchi Teruko Arinaga-Hino Motoki Shimizu Ken Tanikawa Takahiko Tokushige Shingo Hirai Hiroaki Nagamatsu Hideo Tateishi Akio Takata Tatsuya Ide Takuji Torimura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.17, pp.2501-2505, 2019-09-01 (Released:2019-09-01)

参考文献数

14

被引用文献数

3

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We herein report the first case of immune-mediated drug-induced liver injury that may have been caused by laninamivir. A 15-year-old girl was diagnosed with influenza and prescribed 40 mg laninamivir. Six weeks later, she was admitted to our hospital because of jaundice and fatigue. Laboratory examinations revealed elevated levels of hepatobiliary enzymes, and acute liver injury was suspected. Laboratory examinations and histological findings were characteristic of autoimmune hepatitis. Steroid treatment was ineffective, and azathioprine was added to the treatment. Twenty-two months after the onset, a second biopsy revealed the absence of inflammatory infiltrations, and the drugs were withdrawn. Liver function tests remained normal nine months after withdrawal.