- 著者
- Shintaro Mandai Yohei Arai Suguru Hirasawa Toshiyuki Hirai Shota Aki Naoto Inaba Makoto Aoyagi Hiroyuki Tanaka Teiichi Tamura Sei Sasaki
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.51, no.12, pp.1567-1572, 2012 (Released:2012-06-15)
- 参考文献数
- 20
- 被引用文献数
- 4 4
Two patients with anti-centromere antibody (ACA), hypertensive emergency, and acute renal failure, mimicking scleroderma renal crisis, without Raynaud's phenomenon and typical skin manifestations of systemic sclerosis (SSc), are reported. A review of 26 ACA-positive patients between March 2003 and March 2011 in Yokosuka Kyosai Hospital identified four additional patients with similar manifestations. All patients were Japanese women between 41 and 84 years of age at presentation. Human leukocyte antigen (HLA) genotyping tests revealed the absence of the HLA-DQB1*0501 and DRB1*0101 alleles, which are associated with disease susceptibility to ACA-positive SSc among Japanese. These subjects' manifestations may represent a novel entity.