- 著者
- Gyeong Han Jeong Tae Hoon Kim
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.65, no.7, pp.678-682, 2017-07-01 (Released:2017-07-01)
- 参考文献数
- 26
- 被引用文献数
- 4 5
Rutin, a major flavonoid glycoside found in many higher plants, was exposed at 25 kGy of γ-ray and produced three new hydroxymethylated products 2–4 in the C-ring by γ-irradiation. Structures of the new compounds, including absolute configurations, were elucidated based on spectroscopic interpretation (NMR, UV, [α]D, MS, and circular dichroism (CD)). The new unusual rutin derivatives 2 and 3 exhibited significantly enhanced inhibitory effects against α-glucosidase with IC50 values of 23.1±1.2 and 11.2±0.7 µM, respectively, when compared to the parent rutin.