著者

Omori Saori Mabe Katsuhiro Hatanaka Kanako Ono Masayoshi Matsumoto Mio Takahashi Masakazu Yoshida Takeshi Ono Shoko Shimizu Yuichi Sugai Nozomi Suzuki Akira Katsuki Shinichi Fujii Takahiro Kato Mototsugu Asaka Masahiro Sakamoto Naoya

出版者

Elsevier

雑誌

Pathology, Research and Practice (ISSN:03440338)

巻号頁・発行日

vol.210, no.7, pp.440-443, 2014-07

被引用文献数

14

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It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps. (C) 2014 Elsevier GmbH. All rights reserved.