著者

Yuji Hatano Hiroto Shimoyachi Tatsuya Asano Takahiro Kenmotsu Takuro Wada Yasuhisa Oya Hiroaki Nakamura Susumu Fujiwara

出版者

Japan Society for Simulation Technology

雑誌

日本シミュレーション学会英文誌 (ISSN:21885303)

巻号頁・発行日

vol.9, no.1, pp.198-205, 2022 (Released:2022-06-17)

参考文献数

12

被引用文献数

1

---

The goal of this study is to establish a simple experimental system to examine the rate of double strand breaks (DSBs) of genome-sized DNA molecules under irradiation of β-rays from tritium under well-controlled conditions for the validation of computer simulation on interactions of biomolecules and ionizing radiation. Irradiation effects were insignificant at tritium concentration of 1300 Bq/cm3, indicating that the effects of β-rays were far smaller than those of oxidation and/or thermal motion at the low dose rate (4.3 μGy/h). Clear increase in DSB rate was observed at tritium concentrations of 3.0—4.0 MBq/cm3. The temperature dependence of DSB rate was examined by using the high concentration tritiated water.