著者
Ayami Ochi Takashi Takei Kayu Nakayama Chihiro Iwasaki Daigo Kamei Yuki Tsuruta Ari Shimizu Shunji Shiohira Takahito Moriyama Mitsuyo Itabashi Toshio Mochizuki Keiko Uchida Ken Tsuchiya Motoshi Hattori Kosaku Nitta
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.51, no.7, pp.759-762, 2012 (Released:2012-04-01)
参考文献数
15
被引用文献数
17 21

We present two cases with steroid-resistant nephrotic syndrome (SRNS) and two cases with steroid-dependent nephrotic syndrome (SDNS) due to focal segmental glomerulonephritis (FSGS) who were treated with a single dose of rituximab (375 mg/m2). Although the two cases with SRNS showed no response, the two cases with SDNS achieved complete remission. The patients in whom the peripheral B-cell counts subsequently increased after the administration of rituximab demonstrated a relapse. Rituximab may be an effective treatment agent for SDNS with FSGS and the peripheral B-cell count may be a useful marker in such patients for preventing disease relapse.