- 著者
- Tsukasa Saida Ayumi Shikama Kensaku Mori Toshitaka Ishiguro Takeo Minaguchi Toyomi Satoh Takahito Nakajima
- 出版者
- Japanese Society for Magnetic Resonance in Medicine
- 雑誌
- Magnetic Resonance in Medical Sciences (ISSN:13473182)
- 巻号頁・発行日
- pp.mp.2022-0061, (Released:2022-11-12)
- 参考文献数
- 28
- 被引用文献数
- 1
Purpose: To compare MRI findings of high-grade serous carcinoma (HGSC) with and without breast cancer (BRCA) gene variants to explore the feasibility of MRI as a genetic predictor.Methods: We retrospectively reviewed MRI data from 16 patients with BRCA variant-positive (11 patients of BRCA1 and 5 patients of BRCA2 variant-positive) and 32 patients with BRCA variant-negative HGSCs and evaluated tumor size, appearance, nature of solid components, apparent diffusion coefficient (ADC) value, time-intensity curve, several dynamic contrast-enhanced curve descriptors, and nature of peritoneal metastasis. Age, primary site, tumor stage, bilaterality, presence of lymph node metastasis, presence of peritoneal metastasis, and tumor markers were also compared between the groups with the Mann-Whitney U and chi-square tests.Results: The mean tumor size of BRCA variant-positive HGSCs was 9.6 cm, and that of variant-negative HGSCs was 6.8 cm, with no significant difference (P = 0.241). No significant difference was found between BRCA variant-positive and negative HGSCs in other evaluated factors, except for age (mean age, 53 years old; range, 32–78 years old for BRCA variant-positive and mean age, 61 years old; range, 44–80 years old for BRCA variant-negative, P = 0.033). Comparing BRCA1 variant-positive and BRCA2 variant-positive HGSCs, BRCA1 variant-positive HGSCs were larger (P = 0.040), had greater Max enhancement (P = 0.013), Area under the curve (P = 0.013), and CA125 (P = 0.038), and had a higher frequency of lymph node metastasis (P = 0.049), with significance.Conclusion: There was no significant difference in the MRI findings between patients with HGSCs with and without BRCA variants. Although studied in small numbers, BRCA1 variant-positive HGSCs were larger and more enhanced than BRCA2 variant-positive HGSCs with higher CA125 and more frequent lymph node metastases, and may represent more aggressive features.
- 著者
- Masayuki Yamaguchi Kosuke Kojo Mizuki Akatsuka Tomoyuki Haishi Tatsushi Kobayashi Takahito Nakajima Hiroyuki Nishiyama Hirofumi Fujii
- 出版者
- Japanese Society for Magnetic Resonance in Medicine
- 雑誌
- Magnetic Resonance in Medical Sciences (ISSN:13473182)
- 巻号頁・発行日
- pp.tn.2021-0130, (Released:2022-03-23)
- 参考文献数
- 13
We have developed a new device, consisting of a 3-cm RF coil and an immobilizer, to acquire high-resolution MR images of the testis. With the approval of our institutional review board, we conducted an MRI study on a cohort of healthy volunteers to test this device. With the participants in the supine position, we placed the dedicated immobilizer and RF coil on the scrotum for typically no more than 3 min. Subsequently, T2-weighted images were acquired with an in-plane resolution of 117 µm using a 3-T MR scanner and the periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) sequence. The total scan time ranged from 12 to 30 min (average 20 min). High-resolution MR images of the testis were acquired without deterioration by motion artifacts. Our results showed that the combined use of a small RF coil and an immobilizer is a feasible option for acquiring high-resolution MR images of the testis.
- 著者
- Aki TAKAZAKI Kazuo EDA Toshiyuki OSAKAI Takahito NAKAJIMA
- 出版者
- Society of Computer Chemistry, Japan
- 雑誌
- Journal of Computer Chemistry, Japan (ISSN:13471767)
- 巻号頁・発行日
- vol.16, no.4, pp.93-95, 2017 (Released:2017-10-18)
- 参考文献数
- 6
- 被引用文献数
- 1
By selectively investigating the effect of the bond valence using the hypothetical [(PO4)W12O36]3– species having various bond valences, we could clearly reveal the origin of the linear dependence of the LUMO energy (or the redox potential) on the bond valence. The LUMO of the Keggin-type polyoxotungstates mainly consists of W 5d. The energy of W 5d as well as of the LUMO goes down as the bond valence becomes large (i.e., as the net electron population on W decreases due to the electron-withdrawing effect of the μ4-O atoms). This is the origin of the linear dependence of LUMO energy on the bond valence.