著者
Takashi Fujiwara Yohei Maeda
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20210002, (Released:2021-03-20)
参考文献数
6
被引用文献数
1

Mumps deafness is a serious complication of mumps and its risk factors have not been evaluated. Takagi et al. suggested that adolescents and adults have an 8.4 times higher incidence of mumps deafness than children. However, they did not validate the outcome definition of mumps and mumps deafness, and the age-related difference they observed is not the true difference in the incidence of mumps deafness.
著者
Takashi Fujiwara Masanobu Mizuta Eishu Nango Hisanobu Tamaki
出版者
Society for Clinical Epidemiology
雑誌
Annals of Clinical Epidemiology (ISSN:24344338)
巻号頁・発行日
vol.3, no.3, pp.88-95, 2021 (Released:2021-07-01)
参考文献数
22

BACKGROUNDPrimary curative treatment of resectable laryngeal cancer includes surgery and chemoradiotherapy. Other treatment options include radiotherapy, chemoradiotherapy, partial laryngectomy, and total laryngectomy. Larynx-preserving treatments (partial laryngectomy, radiotherapy, and chemoradiotherapy) are recommended in early stage cases, although total laryngectomy is needed in advanced cases. Here, we evaluated trends in treatment strategies and identified the factors that are important in decision making.METHODSWe performed a retrospective analysis of data acquired from electronic medical records in Japan. Hospitalized laryngeal cancer patients admitted between January 2014 and December 2018 were included in our analyses. The primary outcome was the initial treatment.RESULTSA total of 363 patients (mean age 71.8 ± 9.5, male/female = 333/30) met the inclusion criteria. Of these, 10.1% of the patients were treated with total laryngectomy, while 17.9% underwent partial resection, 65.8% received radiotherapy (chemoradiotherapy), and 6.1% had no treatment. Larynx-preserving treatment was used in most T1–2 cases (96.9%), and 40% of the patients with T3 cancer underwent total laryngectomy (adjusted odds ratio 26.7 [95% CI, 9.29-91.6]). Of the T3 cancers that were treated, total laryngectomy was performed in only 26.7% of patients aged ≤65 years, but in more than 50% of those aged >65 years.CONCLUSIONSThis retrospective study showed that larynx-preserving treatments were used in most T1–2 cases, and suggested that T stage is the most important factor affecting decision making in the treatment of laryngeal cancer. Older patients with T3 disease tended to undergo total laryngectomy, and age is an important factor in the decision-making process for cases of T3 laryngeal cancer.