- 著者
- Noriho Sakamoto Hiroshi Ishimoto Shota Nakashima Hirokazu Yura Takuto Miyamura Daisuke Okuno Atsuko Hara Takeshi Kitazaki Tomoyuki Kakugawa Yuji Ishimatsu Minoru Satoh Hiroshi Mukae
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.58, no.6, pp.837-841, 2019-03-15 (Released:2019-03-15)
- 参考文献数
- 19
- 被引用文献数
- 23
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months. Anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM should be included in the differential diagnosis of acute/subacute ILD. Measurement of anti-MDA5 antibody and an intensive immunosuppressive regimen might rescue these patients from RP-ILD.