- 著者
- Yuki Yoshimatsu Kazunori Tobino Takafumi Kawabata Naoki Noguchi Ryo Sato Daisuke Motomura Takuto Sueyasu Kohei Yoshimine Saori Nishizawa Yoshihiro Natori
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.5752-20, (Released:2020-12-07)
- 参考文献数
- 12
- 被引用文献数
- 4
While aspiration pneumonia constitutes the majority of pneumonia cases in the elderly, it remains highly underdiagnosed. We experienced a case of recurrent pneumonia and chronic cough that was later diagnosed as aspiration pneumonia and diffuse aspiration bronchiolitis (DAB) due to recurrent hemorrhaging from an intramedullary cavernous malformation. The patient was finally diagnosed when life-threatening respiratory depression caused emergency attention. This is the first report of hemorrhaging from an intramedullary cavernous malformation diagnosed due to aspiration pneumonia and DAB. These findings highlight the importance of considering aspiration in cases with recurrent pneumonia or chronic chough. The underlying cause may be a life-threatening condition.
- 著者
- Yuki Yoshimatsu Noriyuki Ebi Ryunosuke Ooi Takuto Sueyasu Saori Nishizawa Miyuki Munechika Kohei Yoshimine Yuki Ko Hiromi Ide Kosuke Tsuruno Kazunori Tobino
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.5463-20, (Released:2020-11-02)
- 参考文献数
- 18
- 被引用文献数
- 5
The efficacy of epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) in lung squamous cell carcinoma is said to be low. Thus far, only four cases of osimertinib in lung squamous cell carcinoma have been published. We experienced a case of EGFR mutant lung squamous cell carcinoma in which fifth-line treatment with osimertinib was effective after T790M EGFR mutation turned positive. Osimertinib was resumed after sixth-line chemotherapy was ineffective, showing efficacy again. Osimertinib may be a promising treatment option for EGFR mutant lung squamous cell carcinoma. This is the first report to show its effect in a case of rechallenge after intervening chemotherapy. It may therefore be important to evaluate EGFR in never-smoker lung squamous cell carcinoma patients.