- 著者
- Yoko Kanazawa Yuko Momozono Hideki Yamane Terushi Haradahira Minoru Maeda Masaharu Kojimaa
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.35, no.2, pp.895-897, 1987-02-25 (Released:2009-10-19)
- 参考文献数
- 5
- 被引用文献数
- 8 8
2-Deoxy-2-fluoro-D-glucose (FDG) or its 6-phosphate (FDG-6-P) was detected by19F NMR in the organs and urine of mice previously injected with 2-deoxy-2-fluoro-D-mannose (FDM). This conversion of FDG (-6-P) to FDM (-6-P) in vivo was reversible.
- 著者
- Yoko Kanazawa Satoru Kuribayashi Masaharu Kojima Terushi Haradahira
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.10, pp.4213-4216, 1988-10-25 (Released:2011-02-08)
- 参考文献数
- 9
- 被引用文献数
- 9 10
The metabolic pathway of 2-deoxy-2-fluoro-D-galactose (FDGal) in mice was studied by 19F NMR. Efficient accumulation of FDGal in liver was demonstrated by NMR, which is consistent with the results of Ishiwata et al. using radioactive 18FDGal. The new discovery is that this fluorinated hexose was converted to 2-deoxy-2-fluoro-D-glucose (FDG) through UDP-FDGal and UDP-FDG apparently by the action of UDP-Gal epimerase.