2 0 0 0 OA Spinal Cord Ischemia Following Endovascular Repair of Infrarenal Abdominal Aortic Aneurysm
- 著者
- Shingo Nakai Tetsuro Uchida Yoshinori Kuroda Atsushi Yamashita Eiichi Oba Kimihiro Kobayashi Tomonori Ochiai Mitsuaki Sadahiro
- 出版者
- The Editorial Committee of Annals of Vascular Diseases
- 雑誌
- Annals of Vascular Diseases (ISSN:1881641X)
- 巻号頁・発行日
- vol.13, no.3, pp.335-338, 2020-09-25 (Released:2020-09-25)
- 参考文献数
- 10
- 被引用文献数
- 2
Spinal cord injury (SCI) following endovascular aortic repair (EVAR) for an abdominal aortic aneurysm (AAA) is a rare but serious complication. Case 1 presented with ruptured AAA and shock and underwent emergency EVAR. The patient developed incomplete paraplegia 2 days following EVAR. Case 2, diagnosed with impending rupture of AAA with extremely shaggy aorta, was treated with emergency EVAR. The patient was diagnosed with complete paraplegia soon after EVAR. Case 3 underwent elective EVAR and developed delayed paraplegia 2 weeks later. In EVAR, the etiology of SCI leading to paraplegia is often multifactorial. Surgeons must consider the possibility of SCI-induced paraplegia.
1 0 0 0 OA Development of Acute Adult T-cell Leukemia Following PD-1 Blockade Therapy for Lung Cancer
- 著者
- Kyohei Misawa Hajime Yasuda Hironari Matsuda Munechika Hara Tomonori Ochiai Daisuke Koyama Hina Takano Noriaki Iwao Michiaki Koike
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.61, no.22, pp.3421-3424, 2022-11-15 (Released:2022-11-15)
- 参考文献数
- 24
- 被引用文献数
- 3
Immune checkpoint inhibitors (ICIs) are widely used for the treatment of various cancers. However, paradoxical exacerbation of neoplasms, referred to as "hyperprogressive disease," has been reported in a proportion of patients treated with anti-programmed cell death-1 (PD-1)/PD-1 ligand (PD-L1) blockade. We herein report a case of acute adult T-cell leukemia (ATL) that developed shortly after the administration of nivolumab, a PD-1 inhibitor, to treat non-small-cell lung cancer. There were no signs of ATL before the administration of nivolumab, and seropositivity for human T-cell leukemia virus type-1 (HTLV-1) was confirmed after the development of acute ATL. We speculate that nivolumab likely contributed to the development of acute ATL.