- 著者
- Junko Sato Kouji Kozaki Susumu Handa Takashi Ikeda Ryotaro Saka Kohei Tomizuka Yugo Nishiyama Toshiyuki Okumura Shinichi Hirai Tadashi Ohno Mamoru Ohta Susumu Date Haruki Nakamura
- 出版者
- 一般社団法人 情報処理学会
- 雑誌
- IPSJ Transactions on Bioinformatics (ISSN:18826679)
- 巻号頁・発行日
- vol.6, pp.9-17, 2013 (Released:2013-05-28)
- 参考文献数
- 13
We developed a new information management system, Protein Experimental Information Management System (PREIMS), which has the ontology-based functions for quality control, validation, scalability, and information sharing. Its contents are mainly experimental protocols for the analyses of protein structures and functions, and their results. They are stored separately in the PREIMS database (DB), as the ontology based protocol data and the result data. The synchrotron experimental information was stored as the latter result data in Extensible Markup Language (XML). Furthermore we converted those protocols in the format of Resource Description Framework (RDF) for integration with other biological information resources.
- 著者
- Yasunobu NAKAI Yoshiro ITO Masayuki SATO Kazuhiro NAKAMURA Masanari SHIIGAI Tomoji TAKIGAWA Kensuke SUZUKI Go IKEDA Satoshi IHARA Toshiyuki OKUMURA Masashi MIZUMOTO Koji TSUBOI Akira MATSUMURA
- 出版者
- 社団法人 日本脳神経外科学会
- 雑誌
- Neurologia medico-chirurgica (ISSN:04708105)
- 巻号頁・発行日
- vol.52, no.12, pp.859-864, 2012 (Released:2012-12-25)
- 参考文献数
- 26
- 被引用文献数
- 3
A total of 29 cerebral arteriovenous malformations (AVMs) treated at the University of Tsukuba with multimodality treatment including proton beam (PB) radiotherapy for cerebral AVMs between 2005 and 2011 were retrospectively evaluated. Eleven AVMs were classified as Spetzler-Martin grades I and II, 10 as grade III, and 8 as grades IV and V. For AVMs smaller than 2.5 cm and located on superficial and non-eloquent areas, surgical removal with/without embolization was offered as a first-line treatment. For some small AVMs located in deep or eloquent lesions, gamma knife (GK) radiosurgery was offered. Some AVMs were treated with only embolization. AVMs larger than 2.5 cm were embolized to achieve reduction in size, to enhance the safety of the surgery, and to render the AVM amenable to GK radiosurgery. For larger AVMs located in deep or eloquent areas, PB radiotherapy was offered with/without embolization. Immediately after the treatment, 24 patients exhibited no neurological worsening. Four patients had moderate disability, and 1 patient had severe disability. Three patients suffered brain damage after surgical resection, and 2 patients suffered embolization complications. However, no neurological worsening was observed after either GK radiosurgery or PB radiotherapy, but 3 patients treated by PB radiotherapy suffered delayed hemorrhage. Fractionated PB radiotherapy for cerebral AVMs seems to be useful for the treatment of large AVMs, but careful long-term follow up is required to establish the efficacy and safety.