著者
Senda Joe Ito Keiichi Kotake Tomomitsu Kanamori Masahiko Kishimoto Hideo Kadono Izumi Nakagawa-Senda Hiroko Wakai Kenji Katsuno Masahisa Nishida Yoshihiro Ishiguro Naoki
出版者
Nagoya University Graduate School of Medicine, School of Medicine
雑誌
Nagoya Journal of Medical Science (ISSN:00277622)
巻号頁・発行日
vol.81, no.3, pp.359-373, 2019-08

Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that is often used to prevent stroke and peripheral artery disease, and its administration has shown significant improvements for cognitive impairment. We investigate the potential of cilostazol for reducing or restoring cognitive decline during con-valescent rehabilitation in patients with non-cardioembolic ischemic stroke. The study sample included 371 consecutive patients with lacunar (n = 44) and atherothrombosis (n = 327) subtypes of non-cardioembolic ischemic stroke (224 men and 147 women; mean age, 72.9 ± 8.1 years) who were required for inpatient convalescent rehabilitation. Their medical records were retrospectively surveyed to identify those who had received cilostazol (n = 101). Patients were grouped based on cilostazol condition, and Functional Independence Measure (FIM) scores (total and motor or cognitive subtest scores) were assessed both at admission and discharge. The gain and efficiency in FIM cognitive scores from admission to discharge were significantly higher in patients who received cilostazol than those who did not (p = 0.047 and p = 0.035, respectively); we found no significant differences in other clinical factors or scores. Multiple linear regression analysis confirmed that cilostazol was a significant factor in FIM cognitive scores at discharge (β = 0.041, B = 0.682, p = 0.045); the two tested dosages were not significantly different (100 mg/day, n = 43; 200 mg/day, n = 58). Cilostazol can potentially improve cognitive function during convalescent rehabilitation of patients with non-cardioembolic ischemic stroke, although another research must be needed to confirm this potential.
著者
WAKAI Kenji NAITO Mariko NAITO Toru NAKAGAKI Haruo UMEMURA Osami YOKOTA Makoto HANADA Nobuhiro KAWAMURA Takashi
出版者
日本疫学会
雑誌
Journal of epidemiology (ISSN:09175040)
巻号頁・発行日
vol.19, no.2, pp.72-80, 2009-03-01
参考文献数
31
被引用文献数
3 5

<b>Background: </b>To examine the association between oral health and general well-being, we are currently conducting a nationwide cohort study comprising members of the Japan Dental Association (JDA). Herein, we describe the study design and the profile of the participants at baseline.<BR><b>Methods: </b>From 2001 through 2006, the participants completed a baseline questionnaire that surveyed factors related to lifestyle, general health, and oral health. Morbidity and mortality have been monitored by using information from fraternal insurance programs operated by prefectural dental associations. All respondents provided written, informed consent for participation and the use of their insurance data.<BR><b>Results: </b>A total of 21 272 JDA members participated in the baseline survey (response rate, 36.2%). Their mean age &plusmn; SD was 52.3 &plusmn; 12.3 years; 8.0% were women. Among the respondents, 30.2% of men and 10.7% of women were current smokers; 73.5% of men and 44.8% of women were current drinkers. The cohort scored higher on oral health indices than did the general Japanese population: dentists were more likely to brush their teeth &ge;3 times/day, to have &ge;20 teeth, to have fewer lost teeth, to be free from periodontal diseases, and to have higher General Oral Health Assessment Index scores. There was, however, considerable inter-individual variation in scores on the indices.<BR><b>Conclusions: </b>More than one-third of JDA members participated in the study. Their oral average health status was better than that of the general population. Nevertheless, it will be possible to compare morbidity and mortality between those with better and worse scores on oral health indices.