著者
Hiroki Namikawa Koichi Yamada Hiroki Fujimoto Ken-Ichi Oinuma Yoshihiro Tochino Yasuhiko Takemoto Yukihiro Kaneko Taichi Shuto Hiroshi Kakeya
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.56, no.14, pp.1807-1815, 2017-07-15 (Released:2017-07-15)
参考文献数
37

Objective In recent years, infection caused by extended-spectrum beta-lactamase (ESBL)-producing organisms has become an important issue. However, comparative studies of the bacteremia caused by ESBL Enterobacteriaceae and non-ESBL Enterobacteriaceae are extremely rare in Japan. This study aimed to assess the risk factors and prognosis of patients with bacteremia due to ESBL Escherichia coli (E. coli). Methods The medical records of 31 patients with ESBL E. coli bacteremia and 98 patients with non-ESBL E. coli bacteremia who had been admitted to Osaka City University Hospital between January 2011 and June 2015 were retrospectively reviewed. The patient backgrounds, risk factors for infection, and prognosis were evaluated. Results The male-to-female ratio, mean age, underlying disease, leukocyte count, and C-reactive protein (CRP) level did not differ between the patients in the ESBL E. coli bacteremia and non-ESBL E. coli bacteremia groups. The mean Sequential Organ Failure Assessment (SOFA) score for patients with ESBL and non-ESBL E. coli bacteremia were 3.6 and 3.8, respectively. Further, the mortality did not differ between the two groups (9.7% vs 9.2%). However, the independent predictors associated with ESBL E. coli bacteremia according to a multivariate analysis were the use of immunosuppressive drugs or corticosteroids (p=0.048) and quinolones (p=0.005) prior to isolation. The mortality did not differ between the carbapenem and tazobactam/piperacillin (TAZ/PIPC) or cefmetazole (CMZ) groups for the patients with ESBL E. coli bacteremia. Conclusion Whenever we encountered patients with a history of immunosuppressive drug, corticosteroid, quinolone administration, it was necessary to perform antibiotic therapy while keeping the risk of ESBL E. coli in mind.
著者
Yasuhiko TAKEMOTO Ikuo ARIZONO
出版者
ISCM Forum
雑誌
Innovation and Supply Chain Management (ISSN:21870969)
巻号頁・発行日
vol.7, no.2, pp.52-57, 2013-06-30 (Released:2014-04-02)
参考文献数
11
被引用文献数
2 2

In Japan, books and magazines have been distributed under the resale price maintenance and consignment sale systems. At present, the return rate of books and magazines has reached approximately 40 percent of the quantity of publications under the systems mentioned above. This is a severe problem from the viewpoints of both business and environment. For the purpose to solve this problem, a new sale system where wholesale price is reasonable while buyback price is inexpensive has been programmed and practiced. The wholesale and buyback prices are important contract parameters in the transaction program between publisher and bookstore. In this paper, the publishing supply chain consisting of a publisher and a bookstore is formulated as a mathematical model. Then, we have developed a new approach to solve the collaborative sale contract problem with wholesale and buyback prices as contract parameters.