- 著者
- Nathan Ray Alim Shiki Miyazaki Yasushi Shimoda Masaharu Sugiura Makoto Nakajima Shunsuke Kotani
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.65, no.10, pp.989-993, 2017-10-01 (Released:2017-10-01)
- 参考文献数
- 19
- 被引用文献数
- 8
Chiral phosphine oxide sequentially activates silicon tetrachloride and trichlorosilyl enol ethers to facilitate asymmetric aldol/vinylogous aldol reaction of 4-methoxy-3-penten-2-one and conjugated aldehydes in a highly enantioselective fashion, and the subsequent cyclization produced optically active 2,6-disubstituted 2,3-dihydro-4-pyranones bearing stereogenic centers at a remote position in a single operation.