著者

Mitsuyuki Kuroki Naoki Kamo Yonosuke Kobatake Yukichi Abe Shin-ichi Ishii

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

vol.11, no.2, pp.199-204, 1986 (Released:2008-04-18)

参考文献数

22

被引用文献数

2 2

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Stimulation of polymorphonuclear leukocytes (PMN) by tetravalent concanavalin A (α-ConA) induces membrane depolarization preceding the onset of superoxide anion (O2-) production. Both divalent and monovalent ConA analogues were studied to evaluate the role of valence. Monovalent ConA (m-ConA) was inactive in stimulating O2-production and divalent derivatives were less active than native a-ConA. Similarly, membrane depolarization was dependent on the valency of ConA. m-ConA did not induce a marked change in membrane potential, whereas sustained depolarization occurred with multivalent ConA. The formation of multiple linked interactions between surface receptors may be an important early event in the activation of PMN by ConA.