- 著者
- Toshio YANAGIDA Yoshiharu ISHII
- 出版者
- The Japan Academy
- 雑誌
- Proceedings of the Japan Academy, Series B (ISSN:03862208)
- 巻号頁・発行日
- vol.93, no.2, pp.51-63, 2017-02-10 (Released:2017-02-10)
- 参考文献数
- 61
- 被引用文献数
- 4 14
Single molecule detection has contributed to our understanding of the unique mechanisms of life. Unlike artificial man-made machines, biological molecular machines integrate thermal noises rather than avoid them. For example, single molecule detection has demonstrated that myosin motors undergo biased Brownian motion for stepwise movement and that single protein molecules spontaneously change their conformation, for switching to interactions with other proteins, in response to thermal fluctuation. Thus, molecular machines have flexibility and efficiency not seen in artificial machines.