著者

Yuki Takai Takumi Takamura Shintaro Enoki Moeko Sato Yoko Kato-Unoki Xuchun Qiu Yohei Shimasaki Yuji Oshima

出版者

The Japanese Society of Environmental Toxicology

雑誌

環境毒性学会誌 (ISSN:13440667)

巻号頁・発行日

vol.23, no.1, pp.10-21, 2020-07-21 (Released:2020-07-21)

参考文献数

48

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Tributyltin (TBT) is an organotin compound that disrupts the endocrine system of aquatic organisms, and its obesogenic toxicity to various species is well known. However, the mechanism by which TBT disrupts the endocrine system has not been clarified. Therefore, to investigate the effects of TBT in fish, we exposed juvenile medaka (Oryzias latipes) to TBT and analyzed the gene expression changes using mRNA-Seq. As a result of this analysis, it was clear that toxicity-related genes, such as cytochrome P450 superfamily genes connected to hormonal metabolism, and peroxisomeproliferator-activated receptor signaling pathway genes related to obesity, were significantly affected by TBT. Thus, our mRNA-Seq results identified candidate genes for involvement in the mechanisms of TBT toxicity in TBT-exposed medaka. mRNA-Seq could be a strong tool to investigate and further understand the toxic effects caused by pollutants.