- 著者
- Hajime KATAYAMA Yusuke KAWADA Kimiyoshi KANEKO Takamitsu OSHIYAMA Noriyuki TAKATSU
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.47, no.1, pp.48-53, 1999-01-15 (Released:2008-03-31)
- 参考文献数
- 31
- 被引用文献数
- 9 17
A new type of synthetic inhibitor of DNA topoisomerase I and II was examined and several of these derivatives exhibited strong dual activity against these enzymes. This series of compounds showed high cytotoxic activities against cancer cells, but only a limited number of compounds showed any noticeable activity in an in vivo test against murine P388. Non-specific toxicity was observed in the in vivo tests.