著者

Yasuno Fumihiko Tanimukai Satoshi Sasaki Megumi Ikejima Chiaki Yamashita Fumio Kodama Chiine Hidaka Shin Mizukami Katsuyoshi Asada Takashi

出版者

Elsevier Inc.

雑誌

Neurobiology of aging (ISSN:01974580)

巻号頁・発行日

vol.33, no.11, pp.2633-2640, 2012-11

被引用文献数

28

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We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4–) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4– and E4+, and HDL level in E4–. The combination of hypertension and E4+, but not E4–, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline.