- 著者
- Hayakawa Ichiro Ikedo Akiyuki Chinen Takumi Usui Takeo Kigoshi Hideo
- 出版者
- Elsevier
- 雑誌
- Bioorganic & medicinal chemistry (ISSN:09680896)
- 巻号頁・発行日
- vol.20, no.19, pp.5745-5756, 2012-10
- 被引用文献数
- 17 3
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.