- 著者
- Yoshinaka Shimizu
- 出版者
- The Japanese Society of Oral Pathology
- 雑誌
- Oral Medicine & Pathology (ISSN:13420984)
- 巻号頁・発行日
- vol.2, no.1, pp.17-24, 1997 (Released:2008-04-01)
- 参考文献数
- 39
- 被引用文献数
- 15 26
The objective of this reserch is to investigate the age-related changes of human taste buds in circumvallate papillae by a histomorphometric study. The materials were obtained from 241 Japanese cadavers, ranging in age from 0 to 97 years old. The taste bud numbers in the papilla wall, and the taste bud cell numbers per taste bud section were calculated. The transcriptional activities of taste bud cells and lingual epithelial cells were investigated by the argyrophilic nucleolar organizer regions (AgNORs) technique. The taste bud density and the taste bud cell density in the older age groups was lower than that of the younger age groups. The AgNOR number of lingual epithelial cells decreased significantly in the older age groups, but the taste bud cells did not. Unlike the maintenance of transcrptional activity of taste bud cells, the reduction in the taste bud density and the taste bud cell density may influence taste systems with aging.
- 著者
- Mustafa M. Sami Masahisa Saito Shogo Muramatsu Toshihiko Mikami Kamal Al-Eryani Faleh A. Sawair Rasha Abu Eid Jun Cheng Hisakazu Kikuchi Takashi Saku
- 出版者
- The Japanese Society of Oral Pathology
- 雑誌
- Oral Medicine & Pathology (ISSN:13420984)
- 巻号頁・発行日
- vol.14, no.3, pp.89-97, 2010 (Released:2010-03-30)
- 参考文献数
- 28
- 被引用文献数
- 4 4
Epithelial dysplasia and carcinoma in-situ (CIS) of the oral mucosa are two different borderline grades similar to each other, and it is difficult for pathologists to distinguish these two lesions on hematoxylin and eosin-stained sections only. To support objective differential diagnoses, we have developed a new computer-aided analysis system. The method was based on a comparison of the elevation levels in the drop shape between twin-pairs of neighboring rete ridges. The dissimilarity of the drop shape was defined by the roundness difference between a pair of rete ridge units. All the steps were performed using a graphical user interface. The similarity levels in epithelial dysplasia were higher than those in CIS, whose histopathological diagnoses were conventionally made by experienced pathologists. The developed image processing method showed good promise for the computer-aided pathological assessment of oral borderline malignancies in clinical practice.