著者

RICHMOND Jon D.

出版者

日本動物実験代替法学会

雑誌

Alternatives to animal testing and experimentation : AATEX (ISSN:13440411)

巻号頁・発行日

vol.11, no.3, pp.150-154, 2006-03-30

参考文献数

5

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The 6^th World Congress on Alternatives and Animal Use in the Life Sciences, to be held in Tokyo in August 2007, will provide an international showcase for ideas, case-studies, technologies and practices that will both enhance biomedical research and make better provision for animal welfare.<br>If you wonder why you or your colleagues should attend or participate, then read on.<br><b>General Principles</b><br>Although for some people animal welfare may be considered to be the primary reason to devise and implement improved research methods, the benefits to science and, through the resulting scientific progress, the benefits to society are the main reasons for the scientific community to celebrate and publicise its successes and continue to make progress in these areas.<br>It is generally accepted good animal welfare and good science are inseparable; that one of the hallmarks of good science is that scientifically valid, reproducible experiments seek to identify and eliminate unwanted variables; and that the primary effects directly attributable to the controlled experimental variables can be confused with secondary and tertiary changes if other variables or animal welfare issues are unrecognized or uncorrected.<br>I am clear in my own mind that what are often considered to be 'alternative methods' are in reality 'advanced methods': "alternative" suggests only the animal welfare issues are being addressed - "advanced" emphasises the scientific progress they represent and make possible. <br>Four key concepts have shaped my thinking in this area. &hellip;

著者

Michael Balls

出版者

日本動物実験代替法学会

雑誌

Alternatives to Animal Testing and Experimentation (ISSN:13440411)

巻号頁・発行日

vol.16, no.3, pp.101-110, 2011-12-31 (Released:2012-01-23)

参考文献数

15

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Progress in the development and application of replacement alternative methods is discussed, with particular reference to the new technologies and their use in current initiatives to tackle the problem of drug-induced liver injury. The formidable challenges involved are discussed in terms of improving our understanding of the immense puzzles to be solved, our inability to control events, and the law of unintended consequences. Nevertheless, the future is bright, and the reign of the animal-models-tell-us-all and one-drug suits-all philosophies is rapidly coming to an end.