- 著者
- キム ジョンファン
- 雑誌
- RSC Advances = RSC Advances (ISSN:20462069)
- 巻号頁・発行日
- vol.21, pp.17179-17187, 2016-06
- 被引用文献数
- 17
Inspired by the responsive characteristics of natural fibrous counterparts, triple stimuli, pH-, drug-, and near-infrared (NIR) light-responsive Janus composite nanosheets (JCNs) were investigated. The nanosheets consisted of gold islands sequentially hetero-grafted with three different biocompatible polymers (gum arabic, chitosan, and poly(ε-caprolactone)-b-polyethylene glycol (PEG-b-PCL)) that are hierarchically synthesized by a physical deposition–surface functionalization–chemical exfoliation processes. The JCNs are elastic and go through pH-controlled shape recovery activity in a reversible manner. Remarkably, by anchoring the heat-sensitive PEG-b-PCL on the chitosan side of JCNs, the JCNs are securely self-scrolled when doxorubicin molecules are loaded; and unscrolled to release the drug under remotely controlled NIR-irradiation, with negligible premature release, which mimics the structural behavior of a spore launcher in ferns. Moreover, the scrolled JCNs show exceptional photothermal stability under NIR-laser irradiation and the optical hyperthermal effect is capable of inducing death of tumor cells, as well as bright fluorescence and a targeted photothermal anti-tumor effect under two-photon fluorescence imaging. This enables complex nano-therapeutic drug vehicle development in potential cancer theranosis with low toxic side-effects.
- 著者
- Matsuda Tomoyuki Kim Jungeun Moritomo Yutaka
- 出版者
- The Royal Society of Chemistry
- 雑誌
- RSC Advances (ISSN:20462069)
- 巻号頁・発行日
- vol.2011, no.9, pp.1716-1720, 2011-11
- 被引用文献数
- 9 1
We investigated the thermal expansion properties of metal nitroprussides, MA[Fe(CN)5NO]·zH2O (MA = Mn, Fe, Co, Ni, Cu, Zn, and Cd), which have various network structures, i.e. three-dimensional (3D) cubic (Fm[3 with combining macron]m for MA = Fe, Co, and Ni), distorted three-dimensional (distorted-3D) orthorhombic (Pnma for MA = Mn, Zn, and Cd), and two-dimensional (2D) orthorhombic (Amm2 for MA = Cu) structures. In the cubic system, in which the unbridged NO groups are randomly distributed, isotropic positive thermal expansion was observed. On the contrary, in the orthorhombic system, in which the unbridged NO groups are uniaxially distributed, positive (negative) thermal expansion was observed along (perpendicular to) the uniaxial direction. We interpreted the characteristic thermal responses in terms of the rotational vibrations of the [Fe(CN)5NO] units as well as their steric hindrances due to the network dimensionality.