- 著者
- Bando Hiroshi Ebe Koji Bando Masahiro
- 出版者
- OMICS International
- 雑誌
- Molecular Biology : Open Access (ISSN:21689547)
- 巻号頁・発行日
- vol.7, no.1, 2018-01-24
Discussion concerning Calorie Restriction (CR) and low carbohydrate diet (LCD) has continued for years. Authors have developed research of LCD using super LCD with 12% of carbohydrate. The biology of human aging includes study between human and mammalian such as mice, rhesus monkeys. Moderate CR reduced age-related mortality, incidence of diabetes, cancer, cardiovascular disease. By very low calorie diet (VLCD), body weight can be reduced, but the diabetic pathological state remains. Besides CR and LCD, Zone, Ornish, LEARN Diets and Mediterranean style can be applicable. There are very low-carbohydrate ketogenic diet (VLCKD), Moderate-LCD, High- Carbohydrate Diet, as related with the definition of LCD. Morbus (M) value was investigated for clinical practice of LCD, in which M value was remarkably improved by LCD treatment.
- 著者
- Yue Junming Du Ziyun Zhou Fu-Ming Dong Peixin Pfeffer Lawrence M
- 出版者
- OMICS International
- 雑誌
- Cancer Medicine & Anti Cancer Drugs
- 巻号頁・発行日
- vol.1, no.1, pp.1000103, 2016-03
The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.
- 著者
- Yue Junming Du Ziyun Zhou Fu-Ming Dong Peixin Pfeffer Lawrence M
- 出版者
- OMICS International
- 雑誌
- Cancer Medicine & Anti Cancer Drugs
- 巻号頁・発行日
- vol.1, no.1, 2016-03