著者

Kenneth S. Krane

出版者

Wiley

巻号頁・発行日

1988

著者

Jyrki T.J. Penttinen

出版者

Wiley

巻号頁・発行日

2017

著者

Keisuke Yoshida Taka'aki Taira Yoshiaki Matsumoto Tatsuhiko Saito Kentaro Emoto Toru Matsuzawa

出版者

Wiley

雑誌

Journal of Geophysical Research: Solid Earth (ISSN:21699313)

巻号頁・発行日

vol.125, no.5, 2020-04-23

著者

Imamura Keiko Sakurai Yasuteru Enami Takako Shibukawa Ran Nishi Yohei Ohta Akira Shu Tsugumine Kawaguchi Jitsutaro Okada Sayaka Hoenen Thomas Yasuda Jiro Inoue Haruhisa

出版者

Wiley

雑誌

FEBS Open Bio

巻号頁・発行日

2021-04-06

---

RNAウイルスの感染を阻害する既存薬の同定 --複数の異なるRNAウイルスに対して宿主細胞の感受性を下げることにより感染を抑制する薬剤--. 京都大学プレスリリース. 2021-04-07.iPS cells in drug screenings for COVID-19. 京都大学プレスリリース. 2021-04-07.

著者

Kakui Keiichi Hiruta Chizue Uyeno Daisuke

出版者

Wiley

雑誌

Invertebrate Biology (ISSN:10778306)

巻号頁・発行日

vol.138, no.3, pp.e12257, 2019-09

被引用文献数

3

---

With more than 40,000 species, Malacostraca is the most diverse crustacean class. Most malacostracans are gonochoristic, but simultaneous hermaphrodites are also known. Tanaidacea is one of two malacostracan orders that includes simultaneously hermaphroditic species; so far, simultaneous hermaphroditism has been confirmed externally and internally in only two tanaidacean species, both in the genus Apseudes (Apseudidae). Here we show, through external and internal morphological observations of fixed specimens, that the apseudid Falsapseudes bowmani is a simultaneous hermaphrodite, making Falsapseudes the second tanaidacean genus in which simultaneous hermaphroditism has been confirmed both externally and internally. In this species, the epistome (a projection on the clypeus) was thick and elongate in large specimens but was thin and spiniform in smaller specimens; the brooding of eggs or embryos was observed only in thin-epistome individuals, although a pair of ovaries was confirmed in both thick- and thin-epistome individuals. This suggests that individuals with a thick epistome may act as males while also retaining the female reproductive organs.

著者

E.C. Pielou

出版者

Wiley

巻号頁・発行日

1984

著者

Hiroshi Fujita

出版者

Wiley

巻号頁・発行日

1975

著者

J.R. Hook H.E. Hall

出版者

Wiley

巻号頁・発行日

1991

著者

C. Kittel solutions appendix prepared by C.Y. Fong

出版者

Wiley

巻号頁・発行日

1987

著者

Robert Resnick David Halliday Kenneth S. Krane

出版者

Wiley

巻号頁・発行日

1992

著者

Ralph Hultgren ...

出版者

Wiley

巻号頁・発行日

1963

著者

John David Jackson

出版者

Wiley

巻号頁・発行日

1975

著者

edited by M. Toda ...

出版者

Wiley

巻号頁・発行日

2005

著者

A. Edward Profio

出版者

Wiley

巻号頁・発行日

1976

著者

edited by Lewis Fraas Larry Partain

出版者

Wiley

巻号頁・発行日

2010

著者

John N. Murrell Sydney F.A. Kettle John M. Tedder

出版者

Wiley

巻号頁・発行日

1978

著者

Ikeda Naoya Murata Soichiro Maruyama Takehito Tamura Takafumi Nozaki Reiji Kawasaki Takuya Fukunaga Kiyoshi Oda Tatsuya Sasaki Ryoko Homma Masato Ohkohchi Nobuhiro

出版者

Wiley

雑誌

Hepatology research (ISSN:13866346)

巻号頁・発行日

vol.42, no.1, pp.91-102, 2011

被引用文献数

41

---

Keywords: adenosine; adenosine 5′-triphosphate; cyclic adenosine 5′-monophosphate; hepatic stellate cell; liver fibrosisAim:  Activated hepatic stellate cells (HSC) play a critical role in liver fibrosis. Suppressing abnormal function of HSC or reversion from activated to quiescent form is a hopeful treatment for liver cirrhosis. The interaction between platelets and HSC remains unknown although platelets go through hepatic sinusoids surrounded by HSC. This study aimed at clarifying the hypothesis that platelets control activation of HSC.Methods:  We used human platelets, platelet extracts, and primary or immortalized human HSC. We examined the effect of platelets on the activation, DNA synthesis, type I collagen production, and fibrosis-relating gene expressions of HSC. We investigated what suppressed activation of HSC within platelets and examined the mechanism of controlling activation in vitro.Results:  Platelets and platelet extracts suppressed activation of HSC. Platelets decreased type I collagen production without affecting DNA synthesis. Platelets increased the expression of matrix metallopeptidase 1. As platelet extracts co-cultured with an enzyme of degrading adenosine 5′-triphosphate (ATP) suppressed activation, we detected adenine nucleotides within platelets or on their surfaces and confirmed the degradation of adenine nucleotides by HSC and the production of adenosine. Adenosine and platelets increased the intracellular cyclic adenosine 5′-monophosphate (cAMP), which is important in quiescent HSC. A great amount of adenosine and ATP also suppressed activation of HSC.Conclusion:  Activation of human HSC is suppressed by human platelets or platelet-derived ATP via adenosine-cAMP signaling pathway in vitro. Therefore, platelets have the possibility to be used in the treatment of liver cirrhosis.

出版者

Wiley

巻号頁・発行日

1985

著者

by John A. Riddick William B. Bunger and Theodore K. Sakano

出版者

Wiley

巻号頁・発行日

1986