著者

阿部 信一

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.35, no.8, pp.1035-1048, 1971 (Released:2008-04-14)

参考文献数

50

被引用文献数

4 2

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The aim of the present report is to investigate the pathogenesis of the shoulder-hand syndrome (SHS) coming after myocardial infarction and frequent anginal attacks. Methods The incidence, onset, sex difference, age and the site of infarction were observed as for the cases of myocardial infarction and coronary insufficiency accompanied by SHS, admitted to The 2nd Tokyo National Hospital during past 5 years. EMG were recorded in 14 myocardial infarction and 2 coronary insufficiency cases followed by SHS concerning the following muscles ; Mm. trapezius, deltoideus, biceps brach., triceps brach., brachioradialis, flexor carpi radialis, extensor digitorum communis, abductor digiti quinti, flexor pollicis brev., and extensor pollicis brev.. Moreover, complement fixation reaction (CFR) for the antigen of necrotic heart muscle and cervical cord died from myocardial infarction, electrophoresis and immuno-electrophoresis were attempted in 15 SHS cases. On the other had, to clarify the pathogenesis, animal experiments were performed. Myocardial infarction was artificially made by ligation of the branch of coronary arteries in 55 rabbits. ECG, EMG, evoked EMG, gel diffusion test (Ouchterlony's method) and CFR against the antigen of necrotic heart muscle and involved cervical cord were followed up in these rabbits before and every 2 weeks after the infarction. Then, they were exsanguinated from 4 to 8 weeks after the infarction and pathological studies and immunological studies with fluorescent antibody technique were attempted in these excised section preparation of ischemic heart muscle and cervical cord. Anti-rabbit γ-globulin goat serum conjugated with Fluorescein isothiocyanate was used in that technique and blocking test was simultaneously carried out with unlabelled anti-rabbit γ-globulin goat serum.