著者
Masaya Denda Akira Otaka
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.70, no.5, pp.316-323, 2022-05-01 (Released:2022-05-01)
参考文献数
53

The growing interest in artificial proteins modified by synthetic functional units has fueled the demand for their facile preparation. Native chemical ligation (NCL) enables the chemoselective condensation of peptide thioesters with a cysteine-installed synthetic partner and has enjoyed great success in the production of artificial proteins with up to 100–150 residues. A practical method for converting expressed proteins to the corresponding thioesters should lead to significant progress in the NCL-mediated technology. This account describes our recent contributions to the conversion of naturally occurring peptides to the corresponding thioesters by chemical or chemoenzymatic protocols aiming at their future prevalent use in the preparation of sophisticated protein biologics.

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傳田助教と大髙教授のreviewがChem. Pharm. Bull.誌に掲載されました。 J-STAGE Articles - Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences https://t.co/ZmXPWKT5nJ

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