著者

MASAHITO OHUE YURI MATSUZAKI YUTAKA AKIYAMA

出版者

Japanese Society for Bioinformatics

雑誌

Genome Informatics (ISSN:09199454)

巻号頁・発行日

vol.25, no.1, pp.25-39, 2011 (Released:2011-08-03)

参考文献数

22

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Elucidating protein-RNA interactions (PRIs) is important for understanding many cellular systems. We developed a PRI prediction method by using a rigid-body protein-RNA docking calculation with tertiary structure data. We evaluated this method by using 78 protein-RNA complex structures from the Protein Data Bank. We predicted the interactions for pairs in 78×78 combinations. Of these, 78 original complexes were defined as positive pairs, and the other 6,006 complexes were defined as negative pairs; then an F-measure value of 0.465 was obtained with our prediction system.